禽类干扰素受体介导的抗病毒免疫机制研究进展

doi:10.11843/j.issn.0366-6964.2015.08.001

Abstract

Abstract:

Interferon receptor is a key molecular switch in regulation of host antiviral immune state and expression level of cellular immune cytokines.As an important hub in antiviral signal transduction，the expression level of interferon receptor directly affects the antiviral immune response system in host.To enhance the antiviral immune response of host against the foreign pathogens，the effect of interferon antiviral signaling cascade will be magnified through interferon receptor upon infection.This positive feedback mechanism is the most important immune amplification effect during antiviral immune response，which is also the core response of host to defend viral invasion and proliferation.Research of avian interferon receptors has still been in its infancy，in this paper，a summary has been conducted on the latest research advance in structure and classification of interferon receptor，downstream antiviral proteins，as well as avian interferon receptor-mediated antiviral immune mechanisms.

CLC Number:

S852.4

ZHOU Hao，CHEN Shun，WANG Ming-shu，CHENG An-chun. The Research Progress of Interferon Receptors Mediated Antiviral Immune Mechanism in Avian[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2015, 46(8): 1273-1280.

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The Research Progress of Interferon Receptors Mediated Antiviral Immune Mechanism in Avian

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